General Information

  • ID:  hor007081
  • Uniprot ID:  P60568??22-153)
  • Protein name:  Interleukin-2
  • Gene name:  NDP
  • Organism:  Homo sapiens
  • Family:  IL-2 family
  • Source:  Human
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
  • GO MF:  GO:0005576 extracellular region; GO:0005615 extracellular space
  • GO BP:  GO:0030246 carbohydrate binding; GO:0005125 cytokine activity; GO:0019209 kinase activator activity; GO:0031851 kappa-type opioid receptor binding; GO:0005134 interleukin-2 receptor binding; GO:0008083 growth factor activity; GO:0043208 glycosphingolipid binding
  • GO CC:  GO:0046013 regulation of T cell homeostatic proliferation; GO:0030217 T cell differentiation; GO:0060999 positive regulation of dendritic spine development; GO:0002639 positive regulation of immunoglobulin production; GO:0050729 positive regulation of inflammatory response; GO:0032740 positive regulation of interleukin-17 production; GO:0048304 positive regulation of isotype switching to IgG isotypes; GO:1900100 positive regulation of plasma cell differentiation; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0045591 positive regulation of regulatory T cell differentiation; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:1901327 response to tacrolimus; GO:0032729 positive regulation of type II interferon production; GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein; GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway; GO:2000561 regulation of CD4-positive alpha-beta T cell proli

Sequence Information

  • Sequence:  PTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
  • Length:  132
  • Propeptide:  MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
  • Signal peptide:  MYRMQLLSCIALSLALVTNS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA